Postdoctoral positions:
We are seeking candidates to fill postdoctoral positions in the Laboratory of Gene Regulation and Development (LGRD) at the National Institute of Child Health and Human Development, starting in the Summer of 2004. The LGRD is comprised of seven groups who share state-of-the-art-facilities and who work on various aspects of gene expression and nuclear cell biology. Topics include:
> Mitotic Regulation. (M. Dasso, mdasso@helix.nih.gov). We study two closely linked pathways that control mitotic progression, spindle assembly and interphase nuclear functions: The Ran GTPase pathway and the SUMO-1 conjugation pathway. Projects will involve use of biochemical and cell imaging techniques to study Ran and SUMO-1 in mammalian cells and Xenopus egg extracts.
> Protein Synthesis. (T. Dever, tdever@box-t.nih.gov). Molecular genetic, biochemical, and structural studies analyze the mechanism and regulation of protein synthesis. Ongoing projects include analysis of translation initiation factors IF2/eIF5B and eIF2, and studies on kinase-substrate recognition and viral regulation of kinases that phosphorylate eIF2.
> Gene Regulation in Yeast. (A. Hinnebusch, ahinnebusch@nih.gov). Mechanisms of transcriptional and translational control of gene expression, and signal transduction, are being studied in S. cerevisiae using a combination of genetics, molecular biology and biochemistry. Current projects include the analysis of in vivo coactivator requirements for the transcriptional activator GCN4, assembly and functions of a multifactor complex of translation initiation factors, and regulation of protein kinase GCN2 in nutrient starved cells.
> Retrovirus Models in Yeast. (H. L. Levin, Henry_Levin@nih.gov). LTR-retrotransposons are close relatives of retroviruses that can be readily studied in model organisms such as yeast. We use molecular and genetic techniques to study the function of Tf1, a highly active retrotransposon of the fission yeast Schizosaccharomyces pombe. Current projects focus on the function of host proteins required for the nuclear import of the transposon.
> Developmental Mechanism of Gene Function. (Y.-B. Shi, shi@helix.nih.gov). Thyroid hormone (TH)-dependent amphibian metamorphosis is being investigated as a model system for postembryonic development. Potential projects include investigating the role of chromatin and cofactors in gene regulation by TH receptors in vivo, and the functions of TH-regulated matrix metalloproteinase genes in apoptosis and cell migration.
> Mitotic Chromosome Dynamics. (A. Strunnikov, strunnik@box-s.nih.gov). The project is focused on the mechanisms and cell-cycle regulation of the higher-order chromosome structure, including sister chromatid cohesion and chromosome condensation. The prospective candidate will employ biochemical, genetic and cell biology methods to study chromatin proteins in human and/or yeast cells.
Candidates for these positions should hold either a Ph.D. or M.D., and should have less than five years of postdoctoral experience.
Salary is negotiable, depending upon qualifications ($31,000 per annum or more).
Prospective candidates can address inquiries regarding these positions to the P.I.s listed above at: Laboratory of Gene Regulation and Development
National Institute of Child Health and Human Development
National Institutes of Health
Building 18, Room 106
Bethesda, MD 20892-5431
Phone: 301-496-4045
Fax: 301-402-1323
To apply, they should send their CV and three letters of reference to the same address.
For additional information see: http://eclipse.nichd.nih.gov/nichd/lgrd/
The NIH is an equal opportunity employer.